BEST PUBLICATION:Nature Medicine
PHONE:+45 53 33 80 63
BEST AWARD:High-Tech Award Danish Engineering Society
DegreesM.Sc - Biology - Copenhagen Uni
DegreesPh.D - Neurophysology - Copenhagen Uni
DegreesPostdoc - McMaster Uni
Chief Scientific Officer
Our CSO has a background as biologist from Copenhagen University where he graduated with a masters in electrophysiology and later a Ph.D. being the first to characterize the enteric nervous system in the pig a work that required skillful microsurgery to extract sheets of nerve plexus from the gut for subsequent analysis with sharp microelectrodes with 0.1 µm tips which were freshly prepared in the lab for each experiment, hereto an advanced computer interface was built controlling the setup. Lars Thomsen was awarded a two-year post-doctoral position by the Carlsberg Foundation at McMaster University. A work that was carried out in collaboration with researchers at Panum Institute, Copenhagen. The aim was to cast light on the possible role of the Interstitial Cells of Cajal (ICC) as potential pacemaker cells of the gut. This resulted in a single cell analysis by a combination of anatomical light-microscopy analysis of live cells, patch-clamping and single cell RT-PCR for expression of the KIT gene. The results were published in Nature Medicine in 1998 one of the worlds highest ranking medical journals. The research was hailed as a landmark in the understanding of gastrointestinal motility and general physiological function and settling a two-decade-long debate about the pacemaker function of the ICC’s. The same year it was shown by other researchers that the Interstitial Cells of Cajal is the origin of the most common form for mesenchymal cancer type known as gastrointestinal stromal tumors (GIST’s). The paper has received considerable interest since its publication and is listed in the top 25% of all scientific publications, and in the last two years, it has received 8% of all its citations despite its a 21-year-old publication.