Bedsores is an increasing problem with as the elderly population grows. Antibiotic resistance development is making it even more difficult and sometimes impossible to cure the wounds with prolonged hardship and often fatal outcome. We have an active program to treat antibiotic-resistant infections with our nanotechnology – not limited to bedsores but for sure it is on the list.
Our nanotechnology is generic but can be tailored to different diseases
Our technology has many applications due to its generic nature. This means that the technology can be applied to a range of diseases if its tailored to address the individual cells underlying the cause of the disease:
- Antibiotic Resistant Infections
Cancer covers a range of diseases caused by a variety of genetic and epigenetic factors. Our technology can be compared to a surgical procedure but at the cellular level and with very high precision with the promise that single cells can be removed without harming healthy cells – reducing side effects. Initially, we have a focus on gastrointestinal tumors – with epithelial, gland and smooth muscle origin.
Bacteria and other micro-organisms are rapidly becoming resistant to all known treatments. Recently it has been reported that N. gonorrhoeae now shows resistance to six previously recommended treatment options: sulfonamides, penicillins, earlier generation cephalosporins, tetracyclines, macrolides, and fluoroquinolones. In general antibiotic resistant strains of bacteria can reach us via many routes as indicated in the illustration below and it is not just via sexual transmitted diseases we get exposed to the resistant bacteria – infact ones we have an antibiotic resistant bacteria in our system it can transfer its resistance genes to our normally helpful bacteria like those in our gut.
Routes of transmission 1), as wastewater treatment facilities do not entirely remove antibiotic-resistant bacteria before releasing water into the environment. Another common route is through the application of manure to fields with cultivated crops (2), where antibiotic-resistant bacteria can readily develop on the plants (3). The uptake of these resistant bacteria can then happen through the food chain when humans later consume these plants (4) or the contaminated flesh of animals and fish harboring resistant bacteria (5). As bacteria can easily reach water reserves, water distribution infrastructure is also a potential route for the spread of these germs (6). Even wildlife, insects and other bugs are potential carriers of antimicrobial resistance (7). Tourism, migrations and food imports (8) are nevertheless reported as the fastest way of spreading resistant strains of bacteria across borders. At the healthcare facilities level, resistant bacteria can spread by contact between patients or with healthcare staff, or through contaminated surfaces and medical devices.
The illustration below shows the resistance mechanisms of all known antibiotics
Nanolysis of bacteria using our nanotechnology is a strong technique that can be utilized to stop all sorts of antibiotic-resistant infections. The illustration below shows various mechanisms in which the particles can mediate biological independent killing of bacteria.
Excess visceral fat tissue is very bad for long-term health. Being obese is by some measures as harmful as a smoking habit when it comes to remaining life expectancy. Even modest amounts of excess weight have a measurable negative impact on the future trajectory of health and longevity. There is an enormous mountain of data to support these points, ranging from large human studies to simple but compelling experiments in which the surgical removal of fat from mice leads to extended life spans. Unfortunately, we evolved in an environment of scarcity and so find it a challenge to stay slim in an environment of plenty; this is a high-class problem to have in exchange for an end to unavoidable famine and malnutrition, but a problem nonetheless.
One of the contributing causes of degenerative aging is the growing presence of senescent cells in tissues. While investigating the effects of changes in the amount of fat tissue in mice, researchers here find evidence to suggest that some portion of the damage done by fat tissue occurs because it hosts many more senescent cells than would otherwise be present in the body. These cells produce a mix of inflammatory signals, and may well be a sizeable cause of the well-known link between visceral fat and increased inflammation. Chronic inflammation alone drives a faster progression of most of the common fatal age-related conditions, and that is without considering all of the other damage done due to the signaling produced by senescent cells. As a risk factor, inflammation is an embedded mechanism of developed cardiovascular diseases including coagulation, atherosclerosis, metabolic syndrome, insulin resistance, and diabetes mellitus. It is also associated with the development of non-cardiovascular diseases such as psoriasis, depression, cancer, and renal diseases. Additionally, obese tissue produces less adiponectin, which is a significant predictor of cardiovascular mortality and leads to type-2 diabetes development, metabolic abnormalities, coronary artery calcification, and stroke.
The cellular changes during obesity cause the obese tissue to release pro-inflammatory chemicals that over long term cause severe damage to the body and which reduces the life-span considerably.
Our nanotechnology can be applied to induced programmed cell death in the adipocytes (fat cells) in the obese tissue. The cells will be triggered for removal by the immune system and no tissue necrosis occurs.